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β-Elemene Inhibits Peritoneal Metastasis of Gastric Cancer Cells by Modulating FAK/Claudin-1 Signaling

β-Elemene Inhibits Peritoneal Metastasis of Gastric Cancer Cells by Modulating FAK/Claudin-1 Signaling

Mingming Deng, Ye Zhang, Bofang Liu, Yang Chen, Huicong Song, Ruoxi Yu, Xiaofang Che, Xiujuan Qu, Yunpeng Liu, Xuejun Hu, Xiuying Xu

Phytother Res. 2019 Sep;33(9):2448-2456.

PMID: 31342604

Abstract:

Peritoneal metastasis is common in advanced gastric cancer patients and is typically associated with a worse prognosis. β-Elemene is a natural compound that can be isolated from the Curcuma wenyujin plant and has been widely used in China to treat a variety of cancers. However, the anti-metastatic impacts of β-elemene on gastric cancer remain unknown. In our study, we found that β-elemene significantly inhibited the migration and invasive capacity of gastric cells in vitro and inhibited the capacity of gastric cancer cells to peritoneally diffuse and metastasize in vivo. Mechanistically, we demonstrated that the anti-metastatic effects of β-elemene were exerted by downregulating the expression of Claudin-1. Furthermore, β-elemene was found to inhibit the metastatic capacity of cells by downregulating FAK phosphorylation, which regulated Claudin-1. Overall, our result revealed that β-elemene inhibited peritoneal metastases from gastric cancer by modulating the FAK/Claudin-1 pathway.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP515139	(−)-β-Elemene		515-13-9	Price

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