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Ellagic Acid Inhibits HIV-1 Infection in Vitro: Potential Role as a Novel Microbicide

Ellagic Acid Inhibits HIV-1 Infection in Vitro: Potential Role as a Novel Microbicide

A Promsong, T Chuenchitra, K Saipin, S Tewtrakul, P Panichayupakaranant, S Satthakarn, W Nittayananta

Oral Dis. 2018 Mar;24(1-2):249-252.

PMID: 29480632

Abstract:

Objective:
To investigate the in vitro effects of ellagic acid on HIV-1 replication.
Methods:
Anti-HIV-1 activity of ellagic acid was determined in vitro using X4-tropic HIV-1NPO3 and R5-tropic pBaL Env-recombinant virus. Anti-HIV-1NPO3 activity of ellagic acid was investigated at a multiplicity of infection (MOI) of 0.01. Anti-HIV-1 integrase and protease activities of ellagic acid were tested using in vitro integration and proteolytic cleavage assays.
Results:
Ellagic acid, added either before or after HIV-1NPO3 exposure, suppressed replication of the virus in C8166 cells up to 34%. Ellagic acid showed an anti-integrase IC50 of 8.7 μM. No cytotoxicity of ellagic acid at concentrations ranging from 12.5 to 100 μM was observed.
Conclusion:
We conclude that ellagic acid can inhibit HIV-1 infection without cytotoxicity. Thus, it may be a new effective agent that has potential to be developed as a novel microbicide against HIV-1.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP164014953	1,4-Benzodioxane-6-boronic acid		164014-95-3	Price
AP5943215	1,10-Decyldiphosphonic acid		5943-21-5	Price

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