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Enantiomer Separation of Flavour and Fragrance Compounds by Liquid Chromatography Using Novel Urea-Covalent Bonded Methylated Beta-Cyclodextrins on Silica

Enantiomer Separation of Flavour and Fragrance Compounds by Liquid Chromatography Using Novel Urea-Covalent Bonded Methylated Beta-Cyclodextrins on Silica

Siu-Choon Ng, Teng-Teng Ong, Ping Fu, Chi-Bun Ching

J Chromatogr A. 2002 Aug 30;968(1-2):31-40.

PMID: 12236512

Abstract:

A novel methylated beta-cyclodextrin chiral stationary phase (CSP-ME), which was chemically immobilised onto porous silica via multiple urea-linkages was synthesised. The CSP-ME chiral stationary phase depicted good enantiomer separation abilities for some well-known flavour as well as fragrance compounds using high-performance liquid chromatography under reverse phase conditions. The optimum resolution for alpha-ionone, 3-methyl-alpha-ionone, flavanone, 5-methoxyflavanone, 6-methoxyflavanone, 7-methoxyflavanone, hesperetin, naringenin and taxifolin was achieved using a mobile phase composition consisting of 1 wt.% triethylammonium acetate buffer (pH 4.68)-methanol. The effects of pH of triethylammonium acetate buffer and the methanol-acetonitrile content of the mobile phase composition on their retention time and resolution were examined to optimise the separation conditions.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR43202	Triethylammonium acetate buffer			Price

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