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Enantioselective Additions of Diethylzinc and Diphenylzinc to Aldehydes Using 2-dialkyl-aminomethyl-2'-hydroxy- 1,1'-binaphthyls

Dong-Hyun Ko, Kyoung Hoon Kim, Deok-Chan Ha

Org Lett. 2002 Oct 17;4(21):3759-62.

PMID: 12375937

Abstract:

[reaction: see text] A set of 2-dialkylaminomethyl-2'-hydroxy-1,1'-binaphthyls was prepared and used in the catalytic asymmetric additions of diethylzinc and diphenylzinc to various types of aldehydes. These binaphthyl-based axially chiral amino alcohols show high enantioselectivity in the addition of organozincs to aromatic and aliphatic aldehydes.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP1078586 Diphenylzinc Diphenylzinc 1078-58-6 Price
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