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Enantioselective Biocatalytic Formal α-amination of Hexanoic Acid to L-Norleucine

Alexander Dennig, Somayyeh Gandomkar, Emmanuel Cigan, Tamara C Reiter, Thomas Haas, Mélanie Hall, Kurt Faber

Org Biomol Chem. 2018 Nov 7;16(43):8030-8033.

PMID: 30334043

Abstract:

A three-step one-pot biocatalytic cascade was designed for the enantioselective formal α-amination of hexanoic acid to l-norleucine. Regioselective hydroxylation by P450CLA peroxygenase to 2-hydroxyhexanoic acid was followed by oxidation to the ketoacid by two stereocomplementary dehydrogenases. Combination with final stereoselective reductive amination by amino acid dehydrogenase furnished l-norleucine in >97% ee.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP6064637 2-Hydroxyhexanoic acid 2-Hydroxyhexanoic acid 6064-63-7 Price
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