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Enantioselective Equilibration-Access to Chiral Aldol Adducts of Mandelic Acid Esters

Stefan Scholtis, Andreas Ide, Rainer Mahrwald

Org Lett. 2006 Nov 9;8(23):5353-5.

PMID: 17078716

Abstract:

[Structure: see text] Syn-configured aldol products of mandelic acid esters and aldehydes were synthesized by the catalytic use of amines in the presence of titanium(IV) tert-butoxide. Used along with chiral N-methylephedrine, anti-configured alpha,beta-dihydroxyesters were isolated with a high degree of enantioselectivity for the first time.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP3087396 Titanium(IV) tert-butoxide Titanium(IV) tert-butoxide 3087-39-6 Price
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