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Enantioseparation of a Novel "Click" Chemistry Derived Native Beta-Cyclodextrin Chiral Stationary Phase for High-Performance Liquid Chromatography

Enantioseparation of a Novel "Click" Chemistry Derived Native Beta-Cyclodextrin Chiral Stationary Phase for High-Performance Liquid Chromatography

Yong Wang, Teng-Teng Ong, Lai-Sheng Li, Timothy Thatt Yang Tan, Siu-Choon Ng

J Chromatogr A. 2009 Mar 20;1216(12):2388-93.

PMID: 19185873

Abstract:

A novel native beta-cyclodextrin chiral stationary phase was prepared via "click" chemistry with cuprous iodide-triphenylphosphine complex as the catalyst and applied for enantioseparation of Dns-amino acids, substituted phenyl and phenoxy group modified propionic acids, flavonoids, and some pharmaceutical compounds such as nimodipine, propranolol, brompheniramine and bendroflumethiazide in reversed-phase high-performance liquid chromatography. The studied analytes could be resolved under different separation conditions. The resolution of Dns-DL-Leu could reach 5.08 using a mobile phase consisting of 1% (w/w) triethylammonium acetate buffer (pH 4.11) and methanol (50:50 v/v). The effects of buffer pH and the content of organic modifier on enantioseparation of Dns-amino acids by this novel chiral phase were being investigated. The separation results demonstrate that click chemistry, a versatile reaction, affords a facile approach towards the preparation of stable chiral stationary phases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR43202	Triethylammonium acetate buffer			Price

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