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Encapsulation of Clozapine in Polymeric Nanocapsules and Its Biological Effects

Encapsulation of Clozapine in Polymeric Nanocapsules and Its Biological Effects

Sylwia Łukasiewicz, Krzysztof Szczepanowicz, Karolina Podgórna, Ewa Błasiak, Nather Majeed, Sven Ove Ögren Ogren, Witold Nowak, Piotr Warszyński, Marta Dziedzicka-Wasylewska

Colloids Surf B Biointerfaces. 2016 Apr 1;140:342-352.

PMID: 26774571

Abstract:

Clozapine is an effective atypical antipsychotic drug that unfortunately exhibits poor oral bioavailability. Moreover, the clinical use of the compound is limited because of its numerous unfavorable and unsafe side effects. Therefore, the aim of the present study was the development of a new nanocarrier for a more effective clozapine delivery. Here, clozapine was encapsulated into polymeric nanocapsules (NCs). Polyelectrolyte multilayer shells were constructed by the technique of sequential adsorption of polyelectrolytes (LbL) using biocompatible polyanion PGA (Poly-L-glutamic acid, sodium salt) and polycation PLL (poly-L-lysine) on clozapine-loaded nanoemulsion cores. Pegylated external layers were prepared using PGA-g-PEG (PGA grafted by PEG (polyethylene glycol)). Clozapine was successfully loaded into the PLL-PGA nanocarriers (CLO-NCs) with an average size of 100 nm. In vitro analysis of the interactions of the CLO-NCs with the cells of the mononuclear phagocytic system (MPS) was conducted. Cell biocompatibility, phagocytosis potential, and cellular uptake were studied. Additionally, the biodistribution and behavioral effects of the encapsulated clozapine were also studied. The results indicate that surface modified (by PEG grafting) polymeric PLL-PGA CLO-NCs are very promising nanovehicles for improving clozapine delivery.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP26247790	Poly-L-glutamic acid sodium salt		26247-79-0	Price

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