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Endocannabinoid Turnover

Endocannabinoid Turnover

Christopher J Fowler, Patrick Doherty, Stephen P H Alexander

Adv Pharmacol. 2017;80:31-66.

PMID: 28826539

Abstract:

In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes associated with these events and their characterization. We identify the inhibitor profile for these enzymes and the status of therapeutic exploitation, which to date has been limited to clinical trials for fatty acid amide hydrolase inhibitors. To bring the review to a close, we consider whether point block of a single enzyme is likely to be the most successful approach for therapeutic exploitation of the endocannabinoid system.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP499193543	3-Trimethylsilanylethynyl-pyridine-2-carboxylic acid amide		499193-54-3	Price

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