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Endogenous Adenosine Regulates the Effects of Low-Frequency Stimulation on the Induction of Long-Term Potentiation in CA1 Neurons of Guinea Pig Hippocampal Slices

Endogenous Adenosine Regulates the Effects of Low-Frequency Stimulation on the Induction of Long-Term Potentiation in CA1 Neurons of Guinea Pig Hippocampal Slices

S Fujii, Y Kuroda, K L Ito, M Yoshioka, K Kaneko, Y Yamazaki, H Sasaki, H Kato

Neurosci Lett. 2000 Jan 28;279(2):121-4.

PMID: 10674636

Abstract:

A train of low-frequency afferent stimuli (LFS, 1 Hz, 1000 pulses), given 60 min prior to a tetanus (100 Hz, 100 pulses), suppresses the induction of long-term potentiation (LTP) in which a short-term potentiation decreases gradually back to the pre-tetanic level within 40-50 min (LTP suppression). We investigated the effects of adenosine A1 or A2 receptor antagonists (8-cyclopentyltheophylline (8-CPT) and CP-66713, respectively) on LTP suppression in CA1 neurons of guinea pig hippocampal slices. When the LFS was delivered in the presence of 8-CPT (1 microM), LTP suppression was not significantly affected. However, when LFS was delivered in the presence of CP-66713 (10 microM), LTP suppression was inhibited, leading to successful LTP induction. These results indicate that endogenous adenosine, acting via A2 receptors, is involved in the mechanism of LTP suppression.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP91896570	CP-66713		91896-57-0	Price

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