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Endothelium-dependent Vasorelaxation Induced by L-carnitine in Isolated Aorta From Normotensive and Hypertensive Rats

Endothelium-dependent Vasorelaxation Induced by L-carnitine in Isolated Aorta From Normotensive and Hypertensive Rats

María Dolores Herrera, Rosario Bueno, María Alvarez De Sotomayor, Concepción Pérez-Guerrero, Carmen M Vázquez, Elisa Marhuenda

J Pharm Pharmacol. 2002 Oct;54(10):1423-7.

PMID: 12396307

Abstract:

The aim of this work was to investigate the mechanism of the vasodilatory effect induced by L-carnitine. Relaxation produced by L-carnitine was studied in rat aortic rings with and without functional endothelium, pre-contracted with phenylephrine by adding cumulative doses of L-carnitine (10(-7) to 10(-3) M). The relaxation evoked by L-carnitine reached higher values in aortic rings from spontaneously hypertensive rats than those obtained in arteries from normotensive rats; no relaxation was produced in de-endothelialized arteries. However, in the presence of N(G)-nitro-L-arginine (3 x 10(-5) M, a nitric oxide synthase inhibitor), Ro 68070 (10(-4) M, a thromboxane synthetase inhibitor-thromboxane A2/prostaglandin H2 receptor antagonist) or ICI 192605 (10(-5) M, a thromboxane A2 receptor antagonist) the relaxant response to L-carnitine was significantly inhibited. These results show that L-carnitine induced endothelium-dependent relaxation in the rat aorta and the mechanism of this relaxation appeared to be mostly mediated by endothelial production of nitric oxide but#10; also could involve prevention of the action of cyclooxygenase endothelial products acting on the thromboxane A2/prostaglandin H2 receptor.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP117621644	ICI 192605		117621-64-4	Price

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