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Enhanced Chiral Recognition by γ-cyclodextrin-cucurbit[6]uril-cowheeled [4]pseudorotaxanes

Ling Dai, Wanhua Wu, Wenting Liang, Wentong Chen, Xingke Yu, Jiecheng Ji, Chao Xiao, Cheng Yang

Chem Commun (Camb). 2018 Mar 8;54(21):2643-2646.

PMID: 29469921

Abstract:

Mixing γ-cyclodextrin (γ-CD), cucurbit[6]uril (CB[6]) and tetraammonium-bearing axles together led to a spontaneous formation of γ-CD-CB[6]-cowheeled [4]pseudorotaxanes. The well-defined unsymmetrical cavities thus formed enhance the binding affinity towards chiral amines by factors of several hundreds and show remarkably improved chiral discrimination.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP17465860-B γ-Cyclodextrin γ-Cyclodextrin 17465-86-0 Price
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