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Enhanced Effect of glycyl-L-glutamine on Mouse Preimplantation Embryos in Vitro

Enhanced Effect of glycyl-L-glutamine on Mouse Preimplantation Embryos in Vitro

John D Biggers, Lynda K McGinnis, J A Lawitts

Reprod Biomed Online. 2004 Jul;9(1):59-69.

PMID: 15257821

Abstract:

A comparison of the effects of replacing L -glutamine with either glycyl-L-glutamine or alanyl-L-glutamine in a KSOM-type medium on the development of mouse preimplantation embryos in vitro has been made. Alanyl-L-glutamine has no significant effect on the rates of blastocyst formation, onset or completion of hatching, and on the numbers of inner cell mass and trophectoderm cells that develop. Glycyl-L-glutamine has no effect on the rate of blastocyst formation; it stimulates slightly the onset of hatching, but significantly increases the numbers of inner cell mass and trophectoderm cells that develop. Embryo transfer experiments comparing media containing either glutamine or glycyl-L-glutamine have not produced any gross abnormal fetal development. Recently, alanyl-L-glutamine has been used to replace glutamine in media for the culture of human preimplantation embryos. The results in this paper suggest that glycyl-L-glutamine may be a better choice of dipeptide.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP211446467	Glycyl-L-glutamine		211446-46-7	Price

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