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Enhanced Oral Bioavailability of an Antipsychotic Drug Through Nanostructured Lipid Carriers

Enhanced Oral Bioavailability of an Antipsychotic Drug Through Nanostructured Lipid Carriers

Natarajan Jawahar, Prashant Kumar Hingarh, Radhakrishnan Arun, Jubie Selvaraj, Arigo Anbarasan, Sathianarayanan S, Nagaraju G

Int J Biol Macromol. 2018 Apr 15;110:269-275.

PMID: 29402457

Abstract:

Olanzapine is an atypical antipsychotic, undergoes extensive first pass metabolism, also has poor aqueous solubility and belongs to BCS (Biopharmaceutical Classification System) Class II drug) exhibit low oral bioavailability. To overcome this and to enhance the bioavailability, intestinal lymphatic transport of drugs can be exploited through Nano structured lipid carriers (NLCs). The NLCs were formulated by solvent diffusion method using solid lipid (glyceryl tripalmitate), liquid lipid (castor oil) and surfactants (Pluronic F-68, Soylecithin). The formulated NLCs were characterized for physico-chemical properties, in-vitro release studies and in-vivo oral bioavailability. F6 has shown average particle size of 158.5 nm with PI of 0.115 indicating narrow particle size distribution and follows uni modal distribution. It was found that the batch with stearyl amine has a zeta potential of 28.39 mV which confers stability to the dispersion. Bioavailability studies indicate that there was more than 5½-fold increase in oral bioavailability in case of NLCs (F6) compared to olanzapine suspension which indicates that NLCs provided sustained release of the drugs, and these systems can be the preferred as drug carriers for lipophilic drugs in long term disease conditions such as schizophrenia for enhanced bioavailability.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP555442	Glyceryl tripalmitate		555-44-2	Price

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