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Enhanced Retention of Polymer Physical Characteristics and Mechanical Strength of 70:30 poly(L-lactide-co-D,L-lactide) After Ethylene Oxide Sterilization

Enhanced Retention of Polymer Physical Characteristics and Mechanical Strength of 70:30 poly(L-lactide-co-D,L-lactide) After Ethylene Oxide Sterilization

Anastasia J McManus, Rodney C Moser, Rhiannon B Dabkowski, Kevin A Thomas

J Biomed Mater Res B Appl Biomater. 2007 Aug;82(2):325-33.

PMID: 17238162

Abstract:

This study examined the effect of ethylene oxide (EtO) and electron beam (e-beam) irradiation on the properties of 70:30 poly(L-lactide-co-D,L-lactide). The effects of sterilization upon the polymer physical characteristics and strength retention of the material were examined, both initially and after being subjected to real time ageing. Commercially available 70:30 poly(L-lactide-co-D,L-lactide) material was fabricated into rectangular, cylindrical, screw, and sheet designs, and tested in compression, shear, or tension. Sterilization of 70:30 poly(L-lactide-co-D,L-lactide) by ethylene oxide had a nearly negligible effect on the physical properties of the polymer, regardless of specimen size or manufacturing technique. The molecular weight and inherent viscosity of the specimens decreased by approximately 3% after sterilization by EtO. However, sterilization of 70:30 poly(L-lactide-co-D,L-lactide) by e-beam irradiation resulted in immediate changes to some of the physical properties of the polymer. Specimens sterilized by e-beam irradiation displayed an immediate decrease in inherent viscosity of approximately 67% as compared to the respective nonsterile samples. The immediate decrease in inherent viscosity and molecular weight with e-beam irradiation required approximately 39 weeks of real time ageing of the EtO sterilized parts. At all time points investigated in the present study, the strength retention of the EtO sterilized devices equaled or exceeded that of the e-beam irradiated samples.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS743121	Poly(L-lactide-co-D,L-lactide)			Price

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