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Enhanced Stability of Gold Magnetic Nanoparticles With Poly(4-styrenesulfonic Acid-Co-Maleic Acid): Tailored Optical Properties for Protein Detection

Enhanced Stability of Gold Magnetic Nanoparticles With Poly(4-styrenesulfonic Acid-Co-Maleic Acid): Tailored Optical Properties for Protein Detection

Xiaomei Zhang, Qinlu Zhang, Ting Ma, Qian Liu, Songdi Wu, Kai Hua, Chao Zhang, Mingwei Chen, Yali Cui

Nanoscale Res Lett. 2017 Sep 25;12(1):547.

PMID: 28948523

Abstract:

Gold magnetic nanoparticles (GoldMag) have attracted great attention due to their unique physical and chemical performances combining those of individual Fe3O4 and Au nanoparticles. Coating GoldMag with polymers not only increases the stability of the composite particles suspended in buffer but also plays a key role for establishing point-of-care optical tests for clinically relevant biomolecules. In the present paper, poly(4-styrenesulfonic acid-co-maleic acid) (PSS-MA), a negatively charged polyelectrolyte with both sulfonate and carboxylate anionic groups, was used to coat the positively charged GoldMag (30 nm) surface. The PSS-MA-coated GoldMag complex has a stable plasmon resonance adsorption peak at 544 nm. A pair of anti-D-dimer antibodies has been coupled on this GoldMag composite nanoparticle surface, and a target protein, D-dimer was detected, in the range of 0.3-6 μg/mL. The shift of the characteristic peak, caused by the assembly of GoldMag due to the formation of D-dimer-antibody sandwich bridges, allowed the detection.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP3105553	Maleic acid sodium salt		3105-55-3	Price
AP9080799	Poly(styrenesulfonic acid sodium salt)		9080-79-9	Price

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