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Enhancement of Solute Release From Alginate Scaffold With Embedded Sub-Millimeter Voids

Enhancement of Solute Release From Alginate Scaffold With Embedded Sub-Millimeter Voids

D Bal, S Ganguly

J Biomater Sci Polym Ed. 2014;25(1):51-60.

PMID: 23998388

Abstract:

Alginate scaffold has potential use in the controlled release of drugs, and as 3-D structure for the formation of tissue matrix. This article describes the solute release behavior of alginate scaffold that bears embedded voids of sub-millimeter dimensions. Nitrogen gas was bubbled in a fluidic arrangement to generate uniform and self-aligned bubbles in alginate, prior to the cross-linking by CaCl₂. The cross-linked gel was dried in a vacuum oven, and subsequently, soaked in Vitamin B12 solution. The dimensions of the voids immediately after the cross-linking of gel, and also after complete drying were obtained using a digital microscope and the scanning electron microscope, respectively. The porosity of the gel was measured gravimetrically. The release of Vitamin B12 in water on a shaker was studied. For comparison, the experiment was repeated with a scaffold that did not have any embedded void. The enhancements in uptake and release of Vitamin B12 due to the presence of voids are estimated in this article.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP68199-A	Cyanocobalamin (Vitamin B12) solution		68-19-9	Price

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