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Enhancing Hydrophilicity of Photoacoustic Probes for Effective Ratiometric Imaging of Hydrogen Peroxide

Enhancing Hydrophilicity of Photoacoustic Probes for Effective Ratiometric Imaging of Hydrogen Peroxide

Xiaomei Lu, Meng Zhao, Pengfei Chen, Quli Fan, Wenjun Wang, Wei Huang

J Mater Chem B. 2018 Jul 21;6(27):4531-4538.

PMID: 32254670

Abstract:

Hydrogen peroxide (H2O2) plays a significant role in regulating the redox balance in the living body. Compared with traditional imaging techniques, ratiometric photoacoustic imaging is no doubt a superior choice for H2O2 visualization. However, the difficult design of ratiometric probes with only one activatable agent that exhibits two changeable absorption peaks under H2O2 activation remains a big challenge. In this work, we developed a near-infrared absorbing probe, which responded to H2O2 selectively and permitted the ratiometric photoacoustic imaging of H2O2 in living mice. The probe was constructed from an Aza-BODIPY backbone attached with a benzeneboronic acid pinacol ester moiety though a quaternization reaction. Oligo(ethylene glycol) (OEG) was introduced into hydrophobic Aza-BODIPY to enhance the water-solubility of the probe. The OEG-Aza-BODIPY-BAPE probe exhibited sensitive and specific ratiometric PA signals towards H2O2. In vivo experiments also showed that the OEG-Aza-BODIPY-BAPE probe can be used for ratiometric PA imaging. Overall, our work illustrated a high sensitivity hydrophilic photoacoustic probe for ratiometric imaging of hydrogen peroxide in vitro and vivo.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS793912	2-(e-cyanovinyl)benzeneboronic acid			Price

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