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Enzymatic Detoxification of Organophosphorus Pesticides and Related Toxicants

Enzymatic Detoxification of Organophosphorus Pesticides and Related Toxicants

Karla Alejo-González, Erik Hanson-Viana, Rafael Vazquez-Duhalt

J Pestic Sci. 2018 Feb 28;43(1):1-9.

PMID: 30363124

Abstract:

Millions of cases of pesticide intoxication occur yearly and represent a public health problem. In addition, pesticide poisoning is the preferred suicidal method in rural areas. The use of enzymes for the treatment of intoxication due to organophosphorus pesticides was proposed decades ago. Several enzymes are able to transform organophosphorus compounds such as pesticides and nerve agents. Some specific enzymatic treatments have been proposed, including direct enzyme injection, liposome and erythrocytes carriers, PEGylated preparations and extracorporeal enzymatic treatments. Nevertheless, no enzymatic treatments are currently available. In this work, the use of enzymes for treating of organophosphorus pesticide intoxication is critically reviewed and the remaining challenges are discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AS2121242	Organophosphorus Pesticides			Price

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