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Enzymatic Inactivation of Aztreonam by Faecal Enzyme Preparations From Healthy Volunteers

G W Welling, G Groen, S Welling-Wester, H G de Vries-Hospers, D van der Waaij

Infection. May-Jun 1987;15(3):188-91.

PMID: 3610324

Abstract:

The enzymatic inactivation of aztreonam by the faecal flora was investigated in 25 healthy human volunteers. Ten volunteers received aztreonam orally and 15 volunteers did not receive antibiotic treatment. Residual aztreonam and its inactivated open ring form were simultaneously detected by an HPLC-assay. Independent of aztreonam treatment, beta-lactamase activity was detected in the faecal flora of 20 volunteers. The inactivation of aztreonam by the faecal supernatants was inhibited by clavulanic acid.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP87500741 Open Ring Aztreonam Open Ring Aztreonam 87500-74-1 Price
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