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Enzymatic Synthesis of Methyl Derivatives of L-tryptophan Selectively Labeled With Hydrogen Isotopes

Enzymatic Synthesis of Methyl Derivatives of L-tryptophan Selectively Labeled With Hydrogen Isotopes

Elżbieta Winnicka, Marianna Kańska

Appl Radiat Isot. 2018 Jul;137:118-122.

PMID: 29605584

Abstract:

We report the enzymatic synthesis of the derivatives of L-tryptophan methylated in indole moiety and labeled with deuterium and tritium in the 2-position of side chain. For kinetic studies twelve isotopomers, i.e., 1'-methyl-[2-2H]-, 1'-methyl-[2-3H]-, 1'-methyl-[2-2H/3H]-, 2'-methyl-[2-2H]-, 2'-methyl-[2-3H]-, 2'-methyl-[2-2H/3H]-, 5'-methyl-[2-2H]-, 5'-methyl-[2-3H]-, 5'-methyl-[2-2H/3H]-, 7'-methyl-[2-2H]-, 7'-methyl-[2-3H]-, and 7'-methyl-[2-2H/3H]-L-tryptophan are obtained by the enzymatic coupling of the appropriate methylated indole moiety with S-methyl-L-cysteine catalyzed by the enzyme tryptophanase.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP71271244	Methyl (±)-2-hydroxydecanoate		71271-24-4	Price

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