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Enzymatically Crosslinked poly(2-alkyl-2-oxazoline) Networks for 3D Cell Culture

Enzymatically Crosslinked poly(2-alkyl-2-oxazoline) Networks for 3D Cell Culture

Lucca Trachsel, Nicolas Broguiere, Jan-Georg Rosenboom, Marcy Zenobi-Wong, Edmondo M Benetti

J Mater Chem B. 2018 Dec 14;6(46):7568-7572.

PMID: 32254878

Abstract:

Molecularly designed, random copolymer-bioconjugates based on poly(2-methyl-2-oxazoline) (PMOXA) and poly(2-ethyl-2-oxazoline) (PEOXA) are crosslinked in the presence of sortase A (SA) and human articular chondrocytes (hACs), to yield cellularized polymer networks. Their gelation kinetics and mechanical properties are finely tuned by varying the concentration of SA, while a cell viability >90% is achieved after several weeks of culture, even in the absence of any cell-adhesive cue.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS74609	Poly(2-ethyl-2-oxazoline)			Price

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