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Enzyme Inhibition in Human Skin Homogenates by Hydrocortisone, Hydrocortisone Acetate and Hydrotisone Butyrate

Enzyme Inhibition in Human Skin Homogenates by Hydrocortisone, Hydrocortisone Acetate and Hydrotisone Butyrate

W P Raab, B M Gmeiner

Arch Dermatol Res. 1976 Jun 21;255(3):265-70.

PMID: 942255

Abstract:

In fresh human skin homogenates, the activities of four enzymes, lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PDH), "acid" phosphatase (AcP), and "leucine aminopeptidase" (LAP) were assayed following an incubation with hydrocortisone, hydrocotisone acetate, or hydrocortisone-17-butyrate, respectively. Concentration of the three compounds measured 2.75 mMol/l. Hydrocortison butyrate inhibited LDH-G-6-PDH-, and AcP-activities. Hydrocortisone and hydrocortisone acetate exerted a significant inhibitory action only in the case of G-6-PDH-activity.--On pure G-6-PDH from yeast, the inhibition exerted by hydrocortisone butyrate was significantly stronger than the inhibition exerted by the two other steroids. Time/action diagrams revealed the fact that hydrocortisone butyrate is superior to the other two compounds from the beginning of the incubation period.--The date sustain the assumption that hydrocortisone butyrate exerts biochemical-pharmacological actions of its own and that it may not be considered just as an esterified transport form of hydrocortisone.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP13609671	Hydrocortisone butyrate		13609-67-1	Price

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