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Epicatechin Gallate Protects HBMVECs From Ischemia/Reperfusion Injury Through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization

Epicatechin Gallate Protects HBMVECs From Ischemia/Reperfusion Injury Through Ameliorating Apoptosis and Autophagy and Promoting Neovascularization

Bing Fu, Qinghong Zeng, Zhaoting Zhang, Mingyue Qian, Jiechun Chen, Wanli Dong, Min Li

Oxid Med Cell Longev. 2019 Mar 6;2019:7824684.

PMID: 30962864

Abstract:

Green tea is one of the most beverages with antioxidants and nutrients. As one of the major components of green tea, (-)-epicatechin gallate (ECG) was evaluated for its antioxidative properties in the present study. Cell proliferation assay, tube formation, cell migration, apoptosis, and autophagy were performed in human brain microvascular endothelial cells (HBMVECs) after oxygen-glucose deprivation/reoxygenation (OGD/R) to investigate potential anti-ischemia/reperfusion injury properties of ECG in vitro. Markers of oxidative stress as ROS, LDH, MDA, and SOD were further assayed in our study. Data indicated that ECG could affect neovascularization and promote cell proliferation, tube formation, and cell migration while inhibiting apoptosis and autophagy through affecting VEGF, Bcl-2, BAX, LC3B, caspase 3, mTOR, and Beclin-1 expression. All the data suggested that ECG may be protective for the brain against ischemia/reperfusion injury by promoting neovascularization, alleviating apoptosis and autophagy, and promoting cell proliferation in HBMVECs of OGD/R.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP1257085-A	Epicatechin gallate		1257-08-5	Price

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