Home
Resources
Publications
Epigallocatechin-3-Gallate Protects Erythrocyte Ca(2+)-ATPase and Na(+)/K(+)-ATPase Against Oxidative Induced Damage During Aging in Humans

Epigallocatechin-3-Gallate Protects Erythrocyte Ca(2+)-ATPase and Na(+)/K(+)-ATPase Against Oxidative Induced Damage During Aging in Humans

Prabhanshu Kumar, Pawan Kumar Maurya

Adv Pharm Bull. 2014 Oct;4(Suppl 1):443-7.

PMID: 25364660

Abstract:

Purpose:
The main purpose of this study was to investigate the protective role of epigallocatechin-3-gallate on tertiary butyl hydroperoxide induced oxidative damage in erythrocyte during aging in humans.
Methods:
Human erythrocyte membrane bound Ca(2+)-ATPase and Na(+)/K(+)-ATPase activities were determined as a function of human age. Protective role of epigallocatechin-3-gallate was evaluated by in vitro experiments by adding epigallocatechin-3-gallate in concentration dependent manner (final concentration range 10(-7)M to 10(-4)M) to the enzyme assay medium. Oxidative stress was induced in vitro by incubating washed erythrocyte ghosts with tertiary butyl hydroperoxide (10(-5) M final concentration).
Results:
We have reported concentration dependent effect of epigallocatechin-3-gallate on tertiary butyl hydroperoxide induced damage on activities of Ca(2+)-ATPase and Na(+)/K(+)-ATPase during aging in humans. We have detected a significant (p < 0.001) decreased activity of Ca(2+)-ATPase and Na(+)/K(+) -ATPase as a function of human age. Epigallocatechin-3-gallate protected ATPases against tertiary butyl hydroperoxide induced damage in concentration dependent manner during aging in humans.
Conclusion:
Epigallocatechin-3-gallate is a powerful antioxidant that is capable of protecting erythrocyte Ca(2+)-ATPase and Na(+)/K(+) -ATPase against oxidative stress during aging in humans. We may propose hypothesis that a high intake of catechin rich diet may provide some protection against development of aging and age related diseases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42410452	(±)-Gallocatechin-2,3,4-13C3 gallate			Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: