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(-)-Epigallocatechin 3- O-Gallate as a New Approach for the Treatment of Visceral Leishmaniasis

(-)-Epigallocatechin 3- O-Gallate as a New Approach for the Treatment of Visceral Leishmaniasis

Job D F Inacio, Myslene S Fonseca, Elmo E Almeida-Amaral

J Nat Prod. 2019 Sep 27;82(9):2664-2667.

PMID: 31503486

Abstract:

In addition to generating side effects and resistance, treatment for visceral leishmaniasis remains mostly ineffective and expensive, and it has a long duration. Thus, natural products are an important alternative for treatment of the disease. In this study, we demonstrate the in vitro and in vivo activity of (-)-epigallocatechin 3-O-gallate (1) against Leishmania infantum. Compound 1 reduced the infection index with an EC50 value of 2.6 μM. Oral administration of 1 on L. infantum-infected BALB/c mice was capable to reduce the liver-parasite load with a ED50 and ED90 value of 12.4 and 21.5 mg/kg/day, respectively. Together, the results demonstrated 1 as a new compound for the treatment of visceral leishmaniasis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP989515-A	(−)-Epigallocatechin-3-O-gallate		989-51-5	Price

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