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[Epigenetic Effects Affecting Etoposide Distribution and Metabolism in the Human Body]

[Epigenetic Effects Affecting Etoposide Distribution and Metabolism in the Human Body]

Erika Rozália Kovács, Sára Tóth, Dániel János Erdélyi

Orv Hetil. 2018 Aug;159(32):1295-1302.

PMID: 30078355

Abstract:

Etoposide is a topoisomerase II inhibitor antitumor agent which is widely used in the treatment of several hematologic malignancies and solid tumors. The therapeutic index of etoposide is quite high, thus its application causes several short-term and long-term side effects which can decrease the chance to cure patients. Drug dosing is based on body surface area calculation; recommendations for individual dosing do not exist yet. The biotransformation and transportation of etoposide are carried out by enzymes and transporters as reported in pharmacogenomic studies published in this area. Nowadays pharmacoepigenetics research has come to the fore. The authors wish to give an insight into the research of the epigenetical changes of the etoposide pathways, especially focusing on published findings on enzymes and transporters with pharmacokinetic relevance. In the future, epigenetical changes of the etoposide pathway might have a great role in diagnostics, prognostics and personalized medicine. Orv Hetil. 2018; 159(32): 1295-1302.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP33419420-B	Etoposide		33419-42-0	Price

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