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Epigenetic Mechanisms of the Glucocorticoid Receptor

Epigenetic Mechanisms of the Glucocorticoid Receptor

Andrew A Bartlett, Hannah E Lapp, Richard G Hunter

Trends Endocrinol Metab. 2019 Nov;30(11):807-818.

PMID: 31699238

Abstract:

The glucocorticoid receptor (GR) has been shown to be important for mediating cellular responses to stress and circulating glucocorticoids. Ligand-dependent transcriptional changes induced by GR are observed across numerous tissues. However, the mechanisms by which GR achieves cell and tissue-specific effects are less clear. Epigenetic mechanisms have been proposed to explain some of these differences as well as some of the lasting, even transgenerational, effects of stress and glucocorticoid action. GR functions in tandem with epigenetic cellular machinery to coordinate transcription and shape chromatin structure. Here, we describe GR interactions with these effectors and how GR acts to reshape the epigenetic landscape in response to the environment.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP124555186	GR 79236X		124555-18-6	Price

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