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Epiregulin Induces Human SK-N-BE Cell Differentiation Through ERK1/2 Signaling Pathway

Epiregulin Induces Human SK-N-BE Cell Differentiation Through ERK1/2 Signaling Pathway

Manuela Rizzi, Pamela Pittarella, Maurizio Sabbatini, Filippo Renò

Growth Factors. 2013 Jun;31(3):90-7.

PMID: 23734838

Abstract:

Epidermal growth factor (EGF) and other EGF-related growth factors, such as transforming growth factor-α, are able to stimulate neuroblastoma (NB) cell proliferation. Epiregulin (Epi) is a growth factor belonging to the EGF family known to be more potent than EGF in mediating mitogenic signals. In this study, we tested the ability of Epi to stimulate a human NB cell line (SK-N-BE) proliferation. Surprisingly, Epi (50-1000 ng/ml) induced a reduction in SK-N-BE proliferation along with a morphological differentiation, associated with an increase in MMP-9 expression. Moreover, Epi-induced differentiation was inhibited by ERK1/2 phosphorilation inhibition. In conclusion, Epi could represent a novel and useful tool to oppose NB cell proliferation.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR4248645	Epiregulin human			Price

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