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Epistaxis Risk Associated With Intranasal Corticosteroid Sprays: A Systematic Review and Meta-analysis

Epistaxis Risk Associated With Intranasal Corticosteroid Sprays: A Systematic Review and Meta-analysis

Eric L Wu, William C Harris, Casey M Babcock, Bailin H Alexander, Charles A Riley, Edward D McCoul

Otolaryngol Head Neck Surg. 2019 Jul;161(1):18-27.

PMID: 30779679

Abstract:

Objective:
Intranasal corticosteroids (INCSs) are widely utilized for the treatment of allergic rhinitis. Epistaxis is a known adverse effect of INCSs, but it is not known if the risk of epistaxis differs among INCSs.
Data sources:
Systematic review of primary studies identified through Medline, Embase, Web of Science, PubMed Central, and Cochrane databases.
Review methods:
Systematic review was conducted according to the PRISMA standard. English-language studies were queried through February 1, 2018. The search identified randomized controlled trials of INCSs for treatment of allergic rhinitis that reported incidence of epistaxis. An itemized assessment of the risk of bias was conducted for each included study, and meta-analysis was performed of the relative risk of epistaxis for each INCS.
Results:
Of 949 identified studies, 72 met the criteria for analysis. Meta-analysis demonstrated an overall relative risk of epistaxis of 1.48 (95% CI, 1.32-1.67) for all INCSs. The INCSs associated with the highest risk of epistaxis were beclomethasone hydrofluoroalkane, fluticasone furoate, mometasone furoate, and fluticasone propionate. Beclomethasone aqueous, ciclesonide hydrofluoroalkane, and ciclesonide aqueous were associated with the lowest risk of epistaxis. Conclusions about epistaxis with use of budesonide, triamcinolone, and flunisolide are limited due to the low number of studies and high heterogeneity.
Conclusions:
While a differential effect on epistaxis among INCS agents is not clearly demonstrated, this meta-analysis does confirm an increased risk of epistaxis for patients using INCSs as compared with placebo for treatment of allergic rhinitis.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP77326966	Flunisolide		77326-96-6	Price

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