Home
Resources
Publications
Eponemycin Analogues: Syntheses and Use as Probes of Angiogenesis

Eponemycin Analogues: Syntheses and Use as Probes of Angiogenesis

N Sin, L Meng, H Auth, C M Crews

Bioorg Med Chem. 1998 Aug;6(8):1209-17.

PMID: 9784862

Abstract:

Derivatives of the epoxy-beta-aminoketone containing natural product eponemycin have been prepared in order to study the molecular mode of action of this anti-angiogenic compound. Synthesis and use of a biotinylated dihydroeponemycin analogue demonstrated that dihydroeponemycin forms a covalent adduct with at least two intracellular proteins in human endothelial cells. Pretreatment of cells with a five equivalent excess of dihydroeponemycin precluded biotin-dihydroeponemycin binding indicating a specific interaction between natural product and the target proteins. This biotin-dihydroeponemycin derivative will prove useful in the purification and identification of eponemycin receptors.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP126463647	Dihydroeponemycin		126463-64-7	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: