Home
Resources
Publications
Equivalent Effects on Fecal Reactive Oxygen Species Generation With Oral Supplementation of Three Iron Compounds: Ferrous Sulfate, Sodium Iron EDTA and Iron Polymaltose

Equivalent Effects on Fecal Reactive Oxygen Species Generation With Oral Supplementation of Three Iron Compounds: Ferrous Sulfate, Sodium Iron EDTA and Iron Polymaltose

Monica N Orozco, Claudia Arriaga, Noel W Solomons, Klaus Schümann

Ann Nutr Metab. 2012;60(2):108-14.

PMID: 22414964

Abstract:

Background:
In any context of iron supplementation in the prenatal prophylaxis or therapeutic dosage range, a large amount will remain unabsorbed and pass through the intestinal tract into the colonic digesta possibly causing increased oxidation.
Aim:
To compare the generation of fecal reactive oxygen species (ROS) in situ after daily consumption of 100 mg of elemental iron in three frequently used forms of iron supplements.
Methods:
Ten healthy, iron-repleted adult males were investigated before and during supplementation with three oral iron compounds: 100 mg of oral iron were given as ferrous sulfate, Na Fe-EDTA and iron polymaltose for 6 days to each subject in an individually stratified sequence. Stool samples were collected and analyzed for iron content and the in situ generation of fecal ROS.
Results:
Significant increases in fecal ROS generation were observed during oral iron supplementation. No statistical differences were seen in either residual concentrations of non-heme iron in stool or the level of fecal ROS generation between the three Fe compounds. There was, however, a significant association between the iron concentration in the stool and ROS generation.
Conclusion:
In spite of the differences in their chemical characteristics, none of the three distinct iron complexes reduced oxidative stress in the intestinal lumen.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP18154320	Sodium iron EDTA		18154-32-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: