Home
Resources
Publications
Eradication Efficacy of Modified Dual Therapy Compared With Bismuth-Containing Quadruple Therapy as a First-Line Treatment of Helicobacter Pylori

Eradication Efficacy of Modified Dual Therapy Compared With Bismuth-Containing Quadruple Therapy as a First-Line Treatment of Helicobacter Pylori

Jing Yang, Yi Zhang, Ling Fan, Yang-Jie Zhu, Ting-Yi Wang, Xing-Wei Wang, Dong-Feng Chen, Chun-Hui Lan

Am J Gastroenterol. 2019 Mar;114(3):437-445.

PMID: 30807294

Abstract:

Objectives:
This study assessed the effectiveness, adverse events, patient adherence, and costs of modified dual therapy compared with bismuth-containing quadruple therapy for treating Helicobacter pylori infection in Chinese patients. We also sought to determine whether modified dual therapy could be used as an alternative first-line treatment for H. pylori infection.
Methods:
A total of 232 H. pylori-infected, treatment-naive patients were enrolled in this open-label, randomized controlled clinical trial. Patients were randomly allocated into 2 groups: the 14-day modified dual therapy group and the bismuth-containing quadruple therapy group. Eradication rates, drug-related adverse events, patient compliance, and drug costs were compared between the 2 groups.
Results:
The modified dual therapy group achieved eradication rates of 87.9%, 91.1%, and 91.1% as determined by the intention-to-treat, per-protocol, and modified intention-to-treat analyses, respectively. The eradication rates were similar compared with the bismuth-containing quadruple therapy group: 89.7%, 91.2%, and 90.4%. In addition, modified dual therapy ameliorated variations in the CYP2C19, IL-1B-511, and H. pylori VacA genotypes. There were no significant differences in the compliance rates between the 2 groups. The modified dual therapy group exhibited significantly less overall side effects compared with the bismuth-containing quadruple therapy group (P < 0.001). Furthermore, the cost of medications in the modified dual therapy was lower compared with that in the bismuth-containing quadruple therapy.
Conclusions:
Modified dual therapy at high dose and administration frequency is equally effective and safer and less costly compared with bismuth-containing quadruple therapy.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP22818402	Amoxicillin Related Compound I		22818-40-2	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: