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Erianin, a Novel Dibenzyl Compound in Dendrobium Extract, Inhibits Bladder Cancer Cell Growth via the Mitochondrial Apoptosis and JNK Pathways

Erianin, a Novel Dibenzyl Compound in Dendrobium Extract, Inhibits Bladder Cancer Cell Growth via the Mitochondrial Apoptosis and JNK Pathways

Qiyu Zhu, Yuwen Sheng, Wenhua Li, Jing Wang, Yulin Ma, Baowen Du, Yaxiong Tang

Toxicol Appl Pharmacol. 2019 May 15;371:41-54.

PMID: 30946863

Abstract:

Erianin, a component extracted from the traditional Chinese herbal medicine Dendrobium, has shown significant anti-tumour activity in various cancers but not in bladder cancer. In this study, we assessed the effects of Erianin on bladder cancer growth and elucidated the related mechanisms. First, Erianin was synthesized with high yields, and markedly suppressed EJ and T24 cell proliferation. It induced G2/M-phase arrest in vitro. Furthermore, Erianin triggered apoptosis via caspase cascades activation and the mitochondrial-mediated apoptotic pathway. Bim up-regulation and Bcl-2 down-regulation as the symbol of apoptosis which were found to play the dominant role in the effects of Erianin. We further showed that JNK pathway activation is necessary for the Erianin-mediated anti-proliferation and apoptotic response. Finally, Erianin exhibited anti-tumour activity and induced apoptosis in tumour tissue in vivo. Collectively, these results suggest that Erianin induced cell cycle G2/M-phase arrest and apoptosis via the JNK signalling pathway in bladder cancer, indicating the potential usefulness of Erianin for the therapy of bladder cancer.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP95041900	Erianin		95041-90-0	Price

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