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Erythrodiol-3-acetate, Pentacyclic Triterpenoid From Styrax Japonica, Expressions of Matrix metalloproteinase-1,2 in Cultured Human Skin Fibroblasts

Hyung-In Moon, Dong Wan Seo, Kyu-Han Kim, Kwang-Hyun Cho, Hee-Chul Eun, Jin Ho Chung

J Ethnopharmacol. 2005 Mar 21;97(3):567-71.

PMID: 15740897

Abstract:

Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of erythrodiol-3-acetate on the expressions of MMP-1,2 in cultured human skin fibroblasts. Erythrodiol-3-acetate was isolated from the stems of Styrax japonica (Styracaceae). Erythrodiol-3-acetate reduced the expression of MMP-1 but not MMP-2, at the mRNA and protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that erythrodiol-3-acetate an important role in the reduction of MMP-1 induction by ultraviolet irradiation.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
AP545482 Erythrodiol Erythrodiol 545-48-2 Price
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