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Erythrosin B Inhibits Dopamine Transport in Rat Caudate Synaptosomes

Erythrosin B Inhibits Dopamine Transport in Rat Caudate Synaptosomes

J A Lafferman, E K Silbergeld

Science. 1979 Jul 27;205(4404):410-2.

PMID: 451609

Abstract:

Erythrosin B is a member of a class of fluorescein dyes that are suggested to elicit hyperkinesis when ingested by susceptible children. We found that erythrosin B inhibits dopamine uptake in rat caudate synaptosomes "uncompetitively" in the 10- to 800-micromolar range. Half maximal inhibition of uptake occurred at 45 micromolar. Uncompetitive inhibition denotes a decrease in efficacy of the dopamine membrane transport mechanism with an increase in affinity of dopamine to the carrier. Erythrosin B also decreased nonsaturable binding of dopamine to the synaptosome membrane. The inhibitory action of erythrosin B on dopamine uptake is consistent with the hypothesis that erythrosin B can act as a central excitatory agent able to induce hyperkinetic behavior.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP16423680	Erythrosin B		16423-68-0	Price

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