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ESI-MS Studies of the Reactions of Novel platinum(II) Complexes Containing O,O'-chelated Acetylacetonate and Sulfur Ligands With Selected Model Proteins

ESI-MS Studies of the Reactions of Novel platinum(II) Complexes Containing O,O'-chelated Acetylacetonate and Sulfur Ligands With Selected Model Proteins

Tiziano Marzo, Sandra A De Pascali, Chiara Gabbiani, Francesco P Fanizzi, Luigi Messori, Alessandro Pratesi

Biometals. 2017 Aug;30(4):609-614.

PMID: 28677079

Abstract:

A group of mixed-ligand Pt(II) complexes bearing acetylacetonate and sulphur ligands were recently developed in the University of Lecce as a new class of prospective anticancer agents that manifested promising pharma-cological properties in preliminary in vitro and in vivo tests. Though modelled on the basis of cisplatin, these Pt(II) complexes turned out to exhibit a profoundly distinct mode of action as they were found to act mainly on non-genomic targets rather than on DNA. Accordingly, we have explored here their reactions with two representative model proteins through an established ESI-MS procedure with the aim to describe their general interaction mechanism with protein targets. A pronounced reactivity with the tested proteins was indeed documented; the nature of the resulting metallodrug-protein interactions could be characterised in depth in the various cases. Preferential binding to protein targets compared to DNA is supported by independent ICP-OES measurements. The implications of these findings are discussed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP15170577	Platinum(II) acetylacetonate		15170-57-7	Price

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