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Ethanol Extract of Rehmannia Glutinosa Exerts Antidepressant-Like Effects on a Rat Chronic Unpredictable Mild Stress Model by Involving Monoamines and BDNF

Ethanol Extract of Rehmannia Glutinosa Exerts Antidepressant-Like Effects on a Rat Chronic Unpredictable Mild Stress Model by Involving Monoamines and BDNF

Jun-Ming Wang, Li-Xin Pei, Yue-Yue Zhang, Yong-Xian Cheng, Chun-Ling Niu, Ying Cui, Wei-Sheng Feng, Gui-Fang Wang

Metab Brain Dis. 2018 Jun;33(3):885-892.

PMID: 29468477

Abstract:

The dried roots of Rehmannia glutinosa Libosch. (Scrophulariaceae) are of both medicinal and nutritional importance. Our previous study has found that the 80% ethanol extract of R. glutinosa (RGEE) produced antidepressant-like activities in mouse behavioral despair depression models. However, its mechanisms are still unclear. The present study aimed to observe the antidepressant-like mechanisms of RGEE on a rat chronic unpredictable mild stress (CUMS) model by involving monoaminergic neurotransmitters and brain-derived neurotrophic factor (BDNF). CUMS-stressed rats were orally given RGEE daily (150, 300, and 600 mg/kg) or fluoxetine hydrochloride (FH) for 3 weeks after starting the CUMS procedure. Sucrose preference test was carried out to observe depression-like behavior, and serum and brain tissues were used for neurochemical and fluorescent quantitative reverse transcription PCR analysis. Results demonstrated that CUMS induced depression-like behavior, whereas RGEE and FH administration inhibited this symptom. Furthermore, CUMS caused excessively elevated levels of serum corticosterone (CORT), an index of hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, in a manner attenuated by RGEE and FH administration. RGEE administration also further elevated monoamine neurotransmitters and BDNF levels, up-regulated the mRNA expression of BDNF and tropomyosin-related kinase B (TrkB) in hippocampus of rats suffering CUMS. Together, our findings suggest that RGEE can improve CUMS-evoked depression-like behavior, and indicate its mechanisms may partially be associated with restoring HPA axis dysfunctions, enhancing monoamineergic nervous systems, and up-regulating BDNF and TrkB expression.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP114247095	R-(−)-Fluoxetine hydrochloride		114247-09-5	Price

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