Home
Resources
Publications
Etoposide: Four Decades of Development of a Topoisomerase II Inhibitor

Etoposide: Four Decades of Development of a Topoisomerase II Inhibitor

K R Hande

Eur J Cancer. 1998 Sep;34(10):1514-21.

PMID: 9893622

Abstract:

Podophyllin-containing materials have been used as folk medicines for centuries. In the 1950s, scientists began a search to identify a more effective podophyllotoxin derivative. These efforts eventually resulted in the development of a new class of antineoplastic agents which target the DNA unwinding enzyme, topoisomerase II. The history of the development of one of the first identified topoisomerase II inhibitors, etoposide, is reviewed in this paper. Critical developments in etoposide's mechanism of action, pharmacology and administration schedule are summarised. The clinical benefits of the recently marketed etoposide prodrug, etoposide phosphate (Etopophos) are also detailed. The current status of other clinically approved anticancer agents which target topoisomerase II is briefly reviewed.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP33419420-B	Etoposide		33419-42-0	Price

As a specialist in analytical chemical Products, Alfa Chemistry offers consumers a wealth of raw materials and a full range of technologies and services.

QUICK LINKS

HEADQUARTERS

Tel:

Fax:

Email: