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Eudesmin Impairs Adipogenic Differentiation via Inhibition of S6K1 Signaling Pathway

Eudesmin Impairs Adipogenic Differentiation via Inhibition of S6K1 Signaling Pathway

Ki Hong Nam, Sang Ah Yi, Jaecheol Lee, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Jong Woo Park, Jeung-Whan Han

Biochem Biophys Res Commun. 2018 Nov 10;505(4):1148-1153.

PMID: 30316515

Abstract:

Eudesmin has been reported to possess diverse therapeutic effects, including anti-tumor, anti-inflammatory, and anti-bacterial activities. However, its molecular action has not been implicated in metabolic disease. In this study, we show that treatment of mesenchymal stem cells (MSCs) with eudesmin disturbs adipogenesis via suppression of S6K1 signaling pathway. Eudesmin treatment inhibited activation and nuclear translocation of S6K1. Consequently, S6K1-mediated phosphorylation of H2B at serine 36 (H2BS36p) was reduced upon eudesmin treatment, further inducing the expression of Wnt6, Wnt10a, and Wnt10b, which disturbed adipogenic differentiation. Moreover, eudesmin promoted myogenic and osteogenic gene expression in MSCs. Taken together, we found a novel small molecule, eudesmin, to block adipogenesis through down-regulation of S6K1-H2BS36p axis, followed by regulation of cell fate determination genes. This study suggests a promising therapeutic approach with eudesmin to cure obesity and metabolic diseases.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP29106363	(+)-Eudesmin		29106-36-3	Price

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