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Evaluation of 70/30 Poly (L-lactide-co-D,L-lactide) for Use as a Resorbable Interbody Fusion Cage

Evaluation of 70/30 Poly (L-lactide-co-D,L-lactide) for Use as a Resorbable Interbody Fusion Cage

Jeffrey M Toth, Bradley T Estes, Mei Wang, Howard B Seim 3rd, Jeffrey L Scifert, A Simon Turner, G Bryan Cornwall

J Neurosurg. 2002 Nov;97(4 Suppl):423-32.

PMID: 12449196

Abstract:

Object:
Titanium lumbar interbody spinal fusion devices are reported to be 90% effective in cases requiring single-level lumbar interbody arthrodesis, although radiographic determination of fusion has been debated.
Methods:
Using blinded radiographic, biomechanical, histological, and statistical measures, researchers in the present study evaluated a radiolucent 70/30 poly(L-lactide-co-D,L-lactide) interbody fusion device packed with autograft or recombinant human bone morphogenetic protein-2 on a collagen sponge in 25 sheep at 3, 6, 12, 18, and 24 months. A trend of increased fusion stiffness, radiographic fusion, and histologically confirmed fusion was demonstrated at 3 months to 24 months postimplantation. Device degradation was associated with a mild to moderate chronic inflammatory response at all postoperative sacrifice times.
Conclusions:
Use of this material in interbody fusion may be a viable alternative to metals.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
LS743121	Poly(L-lactide-co-D,L-lactide)			Price

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