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Evaluation of a Novel Oxiconazole Nitrate Formulation: The Thermosensitive Gel

Evaluation of a Novel Oxiconazole Nitrate Formulation: The Thermosensitive Gel

Alper Arslan, Cansel Kose Ozkan, Ali Korhan Sig, Eyup Dogan, Ozgur Esim, Serdar Cetinkaya, Filiz Atalay, Cetin Tas, Ayhan Savaser, Yalcin Ozkan

Saudi Pharm J. 2018 Jul;26(5):665-672.

PMID: 29991910

Abstract:

Superficial fungal infections caused by Candida species are common skin diseases. Therefore, this study aimed to develop a new formulation containing oxiconazole nitrate, which is an azole group derivative for antifungal treatment, as a thermosensitive gel since there has been no literature study until now. MIC value of the novel thermosensitive formulation against three Candida species was calculated and time-dependent antifungal activity analysis was performed. Viscosity, transition temperature Tsol-gel (°C) and gelation time of the thermosensitive gel formulation were also determined in the viscometer. The measurements performed on the tensilometer device were analyzed for adhesion hardness and elongation percentages of the formulation. In the FT-IR spectrometer, the spectrum of solution and gel state was compared between 650 and 4000 cm-1 and it was found that there is no difference between them. It was found that the temperature is reversible on the formulation and did not cause any disruption of its components. Characterization parameters of the thermosensitive gel formulation containing oxiconazole nitrate and time-dependent activity against Candida species was observed to be the same as those of the solution containing only oxiconazole nitrate. MIC, MFC and time-dependent antifungal analysis did not show any particular difference between formulation and oxiconazole nitrate itself. Thermosensitive gel formulation containing oxiconazole nitrate was found to be effective on superficial fungal infections. We believe it is also appropriate for in vivo usage, but it is necessary to perform animal and human research. It is also needed to evaluate the formulation against other etiologic agents of superficial fungal infections.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP64211467-A	Oxiconazole nitrate		64211-46-7	Price

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