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Evaluation of Aluminum Phthalocyanine Chloride and DNA Interactions for the Design of an Advanced Drug Delivery System in Photodynamic Therapy

Evaluation of Aluminum Phthalocyanine Chloride and DNA Interactions for the Design of an Advanced Drug Delivery System in Photodynamic Therapy

Cristiano Ceron Jayme, Italo Rodrigo Calori, Elise Marques Freire Cunha, Antonio Claudio Tedesco

Spectrochim Acta A Mol Biomol Spectrosc. 2018 Aug 5;201:242-248.

PMID: 29753970

Abstract:

The aim of this study was to evaluate the interaction of aluminum phthalocyanine chloride (AlClPc) with double-stranded DNA. Absorption and fluorescence spectra, resonance light scattering, and circular dichroism were evaluated in water and water/ethanol mixtures with different concentrations of DNA or AlClPc. AlClPc showed a high ability to bind to DNA in both water and 4/6 water/ethanol mixture (v/v), with a majority of monomeric and aggregated initial forms of AlClPc, respectively. In this interaction, AlClPc bound preferentially to the grooves of DNA. The monomeric/aggregate state of AlClPc in DNA was dependent on the AlClPc/DNA ratio. At low concentrations of AlClPc, the interaction of AlClPc with few DNA sites caused a curvature in the DNA structure that provided a favorable environment for the intercalation of AlClPc aggregates. Increase in AlClPc concentration induced interactions with a high number of binding sites on DNA, which prevented bending and therefore aggregation of AlClPc molecules throughout the double-stranded DNA. These results are relevant to the understanding of the behavior and interaction of AlClPc with double-stranded DNA in the design of novel drug delivery systems for clinical application in photodynamic therapy as a new approach to treat skin or oral cancer, scars, or wound healing.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP14154428	Aluminum phthalocyanine chloride		14154-42-8	Price

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