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Evaluation of Metoclopramide Hydrochloride as an Aid for Passage of a Flexible Endoscope Into the Duodenum of Dogs

Evaluation of Metoclopramide Hydrochloride as an Aid for Passage of a Flexible Endoscope Into the Duodenum of Dogs

W E Monroe, M S Leib, M E Matz, D J Davenport, L P Nelson, J E Kenny

Am J Vet Res. 1992 Jan;53(1):149-52.

PMID: 1539909

Abstract:

The purposes of this study were to evaluate the efficacy of metoclopramide to aid passage of a flexible endoscope into the duodenum of dogs, and to determine whether the effect of metoclopramide is dependent on dose. In a randomized, blinded, complete-block design, 6 healthy dogs were anesthetized, then each was given saline solution or 1 of 4 doses of metoclopramide on different days. The ease of passage of a flexible, fiberoptic gastroscope through the pylorus was assessed independently by 3 endoscopists. Administration of metoclopramide hydrochloride at a dosage of 0.4 mg/kg of body weight, iv, made passage of a flexible endoscope into the duodenum significantly (P = 0.009) more difficult than when saline solution was administered; however, dosages of 0.1, 0.2 and 0.8 mg of metoclopramide/kg did not (P = 0.489, 0.842, and 0.092 respectively). It was concluded that metoclopramide did not facilitate, and at one dosage hindered, successful passage of a flexible endoscope into the duodenum of healthy dogs under the conditions of the study. Metoclopramide, therefore, cannot be recommended as an aid for passage of a flexible endoscope into the duodenum of dogs.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP54143576	Metoclopramide hydrochloride		54143-57-6	Price

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