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Evaluation of pyrimido[5,4-d]pyrimidine Derivatives as Peroxyoxalate Chemiluminescence Reagents Using a Flow Injection System

Evaluation of pyrimido[5,4-d]pyrimidine Derivatives as Peroxyoxalate Chemiluminescence Reagents Using a Flow Injection System

K Nakashima, K Maki, S Akiyama, K Imai

Biomed Chromatogr. 1990 May;4(3):105-7.

PMID: 2383690

Abstract:

Eighteen kinds of pyrimido[5,4-d]pyrimidines together with several commercially available fluorescent compounds such as perylene, Rhodamine B, etc., were evaluated as the reagents for a peroxyoxalate chemiluminescence (CL) detection system by using a flow injection method. The peroxyoxalate CL reaction employed consists of bis(2,4,6-trichlorophenyl)oxalate, hydrogen peroxide, triethylamine, and a fluorophore. Under the conditions used, 2,6-bis[di-(2-hydroxyethyl)amino]-4,8- dipiperidinopyrimido[5,4-d]pyrimidine (Dipyridamole) and 2,4,6,8-tetrathiomorpholinopyrimido[5,4-d]pyrimidine (1i) gave very intense chemiluminescence intensities which were larger than those of any other commercially available fluorescent compounds tested (e.g., 10 times larger than that of perylene).

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP75203519	Bis(2-carbopentyloxy-3,5,6-trichlorophenyl) oxalate		75203-51-9	Price

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