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Evaluation of Synthetic Cell-Penetrating Peptides, Pro-rich Peptide and Octaargine Derivatives, as Adenovirus Vector Carrier

Evaluation of Synthetic Cell-Penetrating Peptides, Pro-rich Peptide and Octaargine Derivatives, as Adenovirus Vector Carrier

Shinya Kida, Yusuke Eto, Yasuo Yoshioka, Shinsaku Nakagawa, Koichi Kawasaki, Mitsuko Maeda

Protein Pept Lett. 2010 Feb;17(2):164-7.

PMID: 20214640

Abstract:

Two cell-penetrating peptides, a Pro-rich peptide derivative, acetyl-(Val-Arg-Leu-Pro-Pro-Pro)(3)-Gly-Cys amide, and an octaarginine derivative, acetyl-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Cys amide, were prepared by the solid phase method. Each peptide was coupled to the heterobifunctional cross-linking reagent, 6-maleimidohexanoic acid N-hydroxysuccinimide ester, and then conjugated to the Adenovirus vector containing luciferase gene. Peptide-modified Ad, as compared with wild-type Ad, exhibited excellent luciferase activity in B16BL6 cells.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP55750635	6-Maleimidohexanoic acid N-hydroxysuccinimide ester		55750-63-5	Price

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