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Evaluation of Ten Potential Organic Spermicides

Evaluation of Ten Potential Organic Spermicides

P Y Chow, M K Holland, D A Suter, I G White

Int J Fertil. 1980;25(4):281-6.

PMID: 6114050

Abstract:

The following compounds, selected as possible vaginal or cervical spermicides, were tested in vitro for their ability to decrease the motility of human spermatozoa: cytochalasins A and B, N-cetylpyridinium chloride (CPC), N-cetyl-N,N,N-trimethylammonium bromide (CTAB), sodium deoxycholate (SDC), quinine and emetine hydrochlorides, 4-nitrophenyl-4-guanidinobenzoate hydrochloride, n-hexanal, and 6-amidino-2-(4-amidinophenyl) dilactate. The most effective spermicide was the antibacterial cytochalasin A which instantaneously abolished motility at a concentration of 0.01%. The two cationic detergents CPC and CTAB were also very potent and instantly immobilised spermatozoa at a concentration of 0.1%. Quinine, emetine and 4-nitrophenyl-4-guanidinobenzoate hydrochlorides at a concentration of 0.1% abolished motility in 30-60 minutes. n-Hexanal, SDC, and the antihaemostatic compound 6-amidino-2-(4-amidinophenyl) dilactate at 0.1% depressed motility but never rendered the sperm completely immotile. Cytochalasin B had little or no effect on sperm motility even at 0.1%.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP19135172	4-Nitrophenyl 4-guanidinobenzoate hydrochloride		19135-17-2	Price

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