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Evaluation of the Cytotoxicity and Genotoxicity of the Spermicides nonoxynol-9 and octoxynol-9

Evaluation of the Cytotoxicity and Genotoxicity of the Spermicides nonoxynol-9 and octoxynol-9

H S Buttar, S H Swierenga, T I Matula

Toxicol Lett. 1986 Apr;31(1):65-73.

PMID: 3012825

Abstract:

The cytotoxic and genotoxic potentials of the spermicidal agents, nonoxynol-9 (N-9) and octoxynol-9 (0-9), were evaluated in in vitro test systems using rat liver cells. N-9 was also tested for the induction of sperm abnormalities in mice. Dose-related cytocidal effects were seen after the addition of N-9 and O-9 to the culture medium for 24 h. The mean concentrations of N-9 and O-9 necessary to decrease the number of viable cells by 50% (LC50) were 24 and 43 micrograms/ml of media, respectively. The spermicides neither induced DNA repair in freshly isolated hepatocytes, nor caused any mutations at HGPRT locus in the T51B rat liver cell line. There was also a lack of malignant transformation response in the low-calcium assay. Further, the germinal cells of mice remained unaffected by N-9.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP9002931-A	Octoxynol 9		9002-93-1	Price

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