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Evaluation of the Effects of Three Sulfa Sweeteners on the Lifespan and Intestinal Fat Deposition in C. Elegans

Evaluation of the Effects of Three Sulfa Sweeteners on the Lifespan and Intestinal Fat Deposition in C. Elegans

Mohan Zhang, Xin Yang, Wan Xu, Xiaobo Cai, Mingxiang Wang, Yuying Xu, Peilin Yu, Jun Zhang, Yifan Zheng, Jiang Chen, Jun Yang, Xinqiang Zhu

Food Res Int. 2019 Aug;122:66-76.

PMID: 31229125

Abstract:

High sugar content in beverage or food can affect the aging process, and thus natural/artificial sweeteners are widely used as substitutes. However, whether sweeteners have such adverse effects as sugar remains to be clarified. Therefore, in the current study, three sulfa sweeteners, namely, saccharin sodium salt hydrate (SAC2), sodium cyclamate (CYC3) and acesulfame potassium (AceK4) were evaluated for their effects on the lifespan, deposition of lipofuscin, exercise activity, food intake, and intestinal fat deposition (IFD5) of Caenorhabditis elegans (C. elegans6). It was shown that SAC at 0.3 and 10 mg/mL shortened the lifespan of C. elegans and impaired the exercise capacity, while at other concentrations no significant effects were observed. In contrast, CYC at 0.1, 1 and 10 mg/mL prolonged the lifespan of C. elegans. On the other hand, AceK at 1 mg/mL increased the lifespan of C. elegans, and could decrease both lipofuscin deposition and IFD in a dose-dependent manner. Taken together, these results indicated that although SAC, CYC, and AceK all belong to the sulfa sweeteners, each has distinct effects on different physiological activities associated with aging, at least in C. elegans.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
IAR42411261	2-Keto-3-methylbutyric acid-3-d sodium salt hydrate			Price

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