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Evidence for Cardiomyocyte Renewal in Humans

Evidence for Cardiomyocyte Renewal in Humans

Olaf Bergmann, Ratan D Bhardwaj, Samuel Bernard, Sofia Zdunek, Fanie Barnabé-Heider, Stuart Walsh, Joel Zupicich, Kanar Alkass, Bruce A Buchholz, Henrik Druid, Stefan Jovinge, Jonas Frisén

Science. 2009 Apr 3;324(5923):98-102.

PMID: 19342590

Abstract:

It has been difficult to establish whether we are limited to the heart muscle cells we are born with or if cardiomyocytes are generated also later in life. We have taken advantage of the integration of carbon-14, generated by nuclear bomb tests during the Cold War, into DNA to establish the age of cardiomyocytes in humans. We report that cardiomyocytes renew, with a gradual decrease from 1% turning over annually at the age of 25 to 0.45% at the age of 75. Fewer than 50% of cardiomyocytes are exchanged during a normal life span. The capacity to generate cardiomyocytes in the adult human heart suggests that it may be rational to work toward the development of therapeutic strategies aimed at stimulating this process in cardiac pathologies.

Chemicals Related in the Paper:

Catalog Number	Product Name	Structure	CAS Number	Price
AP77108408	Troponin I from human heart		77108-40-8	Price

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